AGS Gastric Cells: Antioxidant Activity and Metabolic Effects of Phenolic Extracts from Different Monocultivar Virgin Olive Oils

The effects of the phenolic compounds extra virgin olive oil (EVOO) on AGS cells have never been studied so far, which is aim this study. profiles main components in EVOOs, mainly secoiridoid derived from transformation oleuropein during milling process, were evaluated and compared. Oils different origins aiming at verifying whether chemical differences composition dry extracts played a role metabolism maintaining cellular redox state cells. following key enzymes some metabolic pathways studied: lactate dehydrogenase, enolase, pyruvate kinase, glucose 6-phosphate citrate synthase, 3-Hydroxyacyl-CoA dehydrogenase hexokinase. As confirmed through PCA analysis, pretreatments with EVOOs concentrations appeared to be able counteract enzymatic activity alterations due oxidative stress induced by H2O2 1 mM 2 mM. phytocomplexes showed ability protect damage derivatives both ligstroside contributed observed effects. results suggested that medium high phenols can exert protection.